The London School of Hygiene & Tropical Medicine (LSHTM) is a global centre of excellence in public health, pathogen research, and tropical medicine, ranked as the world’s leading research-focused graduate school. There is a strong focus on the application of 'omic technologies to infectious diseases covering pathogens, vectors and hosts and on genetic epidemiology of global non-communicable diseases. We are one of the partners in the Farr Institute of Health Informatics Research, London.
High throughput sequencing technologies is leading to important insights into hospital-acquired infections, malaria, trachoma, , tuberculosis, and other infectious diseases, leading to discoveries in drug efficacy and resistance in trypanosomiasis (Alsford, Kelly), TB drug resistance, spatial and mathematical modeling of TB transmission (Clark, Glynn), and other whole genome approaches to uncover population diversity, human and microbe, leading to key host-pathogen interactions impacting on disease (Hibberd, Wren).
Our work on host genetics in non-communicable disease (Dudbridge, Casas, Peto, Silva) includes the development of predictive markers for screening in breast cancer, demarcation of causal pathways in cardiovascular disease, including Mendelian randomisation methodology, and integration of genetic, metabolomic and epigenetic data in cardiovascular and psychiatric disease. This includes substantial development of statistical methodology.
Through The African Partnership for Chronic Disease Research, LSHTM and the Sanger Institute are working with several leading centres across sub-Saharan Africa to strengthen expertise and undertake large scale collaborative genomic studies of particular relevance and value to African populations (Sandhu, Smeeth). UK based work includes an innovative new programme integrating–omics with electronic health records in primary care (Sandhu, Smeeth).